Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/267731058?client_source=feed&format=rss
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Sunday, December 2, 2012
"Twilight" shines in third box office win over Bond
LOS ANGELES (Reuters) - The "Twilight" teen movie vampires sucked more money out of theaters over the weekend, leading James Bond, Brad Pitt and the rest of box office pack with $17.4 million in U.S. and Canadian ticket sales and scoring its third weekly win.
Pitt's new movie, the small-budget gangster film "Killing Them Softly," bombed with filmgoers who panned it with a rare "F" grade on average in polling by audience survey firm CinemaScore. The movie landed in seventh place with $7 million in ticket sales at domestic theaters.
The results were much brighter for "Breaking Dawn - Part 2," the fifth and final film in the "Twilight" vampire and werewolf saga, which has earned $254.6 million at North American (U.S. and Canadian) theaters since its smash debut on November 16.
The top rankings were similar to last week's Thanksgiving holiday weekend.
Bond movie "Skyfall" starring Daniel Craig as superspy 007 grabbed $17 million and held on to second place, according to studio estimates compiled by Reuters. Steven Spielberg's historical drama "Lincoln," featuring a critically acclaimed performance by Daniel Day-Lewis as the 16th U.S. president, kept the No. 3 slot with $13.5 million.
A week ago, "Breaking Dawn - Part 2" and "Skyfall" helped push the five-day Thanksgiving weekend to a box office record. The success of the two films, plus upcoming releases such as fantasy prequel "The Hobbit" and musical "Les Miserables," are likely to power 2012 ticket sales to an all-time high, according to industry forecasts.
As of Sunday, year-to-date sales were running 5.9 percent ahead of the same point in 2011 at $9.9 billion, box office tracker Hollywood.com said.
Critics were kinder than audiences to Pitt's "Killing Them Softly." Seventy-nine percent of reviews collected on the Rotten Tomatoes website applauded the film, which blends a violent but comic gangster story with criticism of politicians' failure to address the economic crisis.
In the movie, Pitt plays a hitman brought in by mafia bosses to eliminate a group of thieves who raid a high-stakes poker game. The film is set in an unspecified U.S. city marked by abandoned houses, closed shops and petty criminals and mobsters trying to get by.
The Weinstein Company distributed the movie, which was produced for less than $20 million by Annapurna Pictures, Inferno Entertainment, and Pitt's production company, Plan B Entertainment.
In the No. 4 slot, family movie "Rise of the Guardians" captured $13.5 million. The Dreamworks Animation film has taken in $48.9 million since its Thanksgiving weekend debut, one of the slowest starts for a movie from the studio behind "Shrek" and "Kung Fu Panda."
"Guardians" features the voices of Chris Pine and Alec Baldwin as the Tooth Fairy, Santa Claus and other childhood favorites who save the world.
Rounding out the top five, survival story "Life of Pi" earned $12 million and fifth place. The critically praised film from director Ang Lee is based on a book about a boy stranded on a boat with an adult Bengal tiger. Its two-week domestic total reached $48.4 million.
The other nationwide release, horror thriller "The Collection," took in $3.4 million and finished in tenth place. The movie, a sequel to 2009 movie "The Collector," tells the story of a serial killer who kidnaps women.
"Breaking Dawn - Part 2" was released by Summit Entertainment, a unit of Lions Gate Entertainment. Sony Corp's movie studio distributed "Skyfall."
"Lincoln" was produced by Dreamworks and distributed by Walt Disney Co. Viacom Inc's Paramount studio distributed "Rise of the Guardians." News Corp's 20th Century Fox studio released "Life of Pi," and LD Entertainment distributed "The Collection."
(Reporting By Lisa Richwine and Christine Kearney; Editing by Cynthia Osterman)
Source: http://news.yahoo.com/twilight-shines-third-box-office-win-over-bond-172023122--finance.html
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New Wordpress "Sites for Restaurants" - There is No Excuse for a ...
I?ve often thought it had great potential for restaurant websites, but using the system to display menus could be time-consuming, and the results weren?t too great. Now that has all changed, with the announcement this morning of ?WordPress Sites for Restaurants?.
The new templates make it easy to create an entire website with built-in Open Table reservations, simple menus with drag and drop editing, maps, hours, full screen images etc. Even better, the whole site will be mobile ready, so your customers can view all the information while they are on the go. If you have or want a custom url, you can transfer it over for $13 a year.
This sounds like I am pimping for WordPress, but I know how many thousands of dollars are?unnecessarily?spent on the average restaurant website. For those with basic needs, it?s just not necessary. For a test, I opened a WordPress account and created a restaurant website with all the usual pages including a menu in less than an hour.
Here is the url for the announcement.
"I have a wide-range of food experience - working in the restaurant industry on both sides of the house, later in the wine industry, and finally traveling/tasting my way around the world. Whether you agree or disagree, you can always count on my unbiased opinion. I don't take free meals, and the restaurants don't know when, or if, I am coming."
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Molecular knock-out alleviates Alzheimer's symptoms in mice
ScienceDaily (Nov. 30, 2012) ? Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center G?ttingen (UMG) have identified an enzyme as a possible target for the treatment of Alzheimer's disease. The protein known as HDAC6 impairs transport processes within the nerve cells. The scientists observed only mild symptoms of the disease in mice if the enzyme was not produced. They propose to block its activity in a targeted fashion to treat the disease. Scientists from the DZNE sites in G?ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease.
The study is published in EMBO Molecular Medicine.
The researchers led by Prof. Andr? Fischer, Department of Psychiatry and Psychotherapy at the University Medical Center Gottingen and Site Speaker of the DZNE in G?ttingen, investigated mice with a modified genetic background. The animals showed behavioural disorders and brain deposits that are typically associated with Alzheimer's disease. The researchers went a step further with a group of other animals by removing the genes responsible for the production of the HDAC6 enzyme (histone deacetylase 6). This intervention proved to be effective: while these mice also exhibited the pathological features of Alzheimer's disease in the brain, their behaviour was significantly ameliorated. "The animals' ability to learn and to find their spatial bearings was relatively normal," says Prof. Fischer. "Their cognitive abilities were fully comparable to those of healthy mice."
Improved cellular traffic
In the researchers' view, this effect is at least partly attributable to the fact that important transport processes within the nerve cells are facilitated when the HDAC6 enzyme is not around. This meant in particular that the cells' power plants, also known as "mitochondria," can travel to their final destinations. "It is known that in various neurodegenerative diseases cellular transport is no longer functional. The substances that are to be transported along axons are left behind," Fischer says. "Measures which improve trafficking seem to have a positive effect."
Possible target for therapy?
The researchers' findings suggest that the HDAC6 enzyme could be a possible target for therapies against Alzheimer's disease. However, treatments would require an active substance that can disable the enzyme in a targeted fashion. Unfortunately, the active substances known to date are too unspecific. Prof. Fischer explains that their application resembles a broad-spectrum treatment: "We don't know precisely what is the therapeutic effect of the inhibitors, since they simultaneously block several enzymes from the histone deacetylase family," he says. "And we still don't know enough about how the individual enzymes function."
Improving the accuracy of the inhibitors is therefore the aim of further research. "We will continue to work toward this goal. On one hand, we want to improve our understanding of how the various histone deacetylases function. On the other hand, we want to test inhibitors that operate in a more targeted manner," says Prof. Andr? Fischer.
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The above story is reprinted from materials provided by Helmholtz Association of German Research Centres.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schl?ter, Frank Bradke, Jianrong Lu, Andr? Fischer. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Molecular Medicine, 2012; DOI: 10.1002/emmm.201201923
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ljCUFV1QTrs/121130121600.htm
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Saturday, December 1, 2012
Which Star?s Daughter Was Named Miss Golden Globe?
Francesca Eastwood, the 19-year-old daughter of Clint Eastwood, was recently named Miss Golden Globe 2013 by the Hollywood Foreign Press Association.
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Top Search Engine PPC Platforms - Online Media Magic
The most popular search engine PPC program is Google AdWords which reaches over 10 billion web pages and 100 different language versions. The benefits of using Google are its inexpensive start-up cost ($5 dollars) and the amount of traffic you will get, which is far more than that of any of the other search engines. Google also provides you with its Google Analytics program, which helps you with what keywords you should be targeting in your PPC ads, a website optimizer, which allows you to test different variations of your web pages to see which convert better, and step-by-step tutorials that take you through the whole process of setting up a Google Adwords campaign. Most experts agree that it is a good idea to start out with Google Adwords, because of the low start-up fee and the heavy traffic. Although it is expensive for competitive terms, you can still get away with not bidding too much on the less competitive longer-tailed keywords. According to thesearchguru blog, on the Internet, organic search drives 75%+ of all search traffic and papy per click receives less than 25% of all search traffic; yet pay per click earns 80%+ of search engine marketing campaign budgets.
The Yahoo Search Marketing search engine PPC platform was first named as GoTo, then changed to Overture, and finally ended up as what we know it today: Yahoo Search Marketing. Yahoo charges a $30 start-up fee, but then offers you $25 of free ads. Yahoo focuses on sponsored Search and reaches over 80% of active Internet users. You can also reach your market through online publishers, newsletters and emails. Instead of your ad appearing only in search rankings, it will also show up next to content like articles and product reviews that are related to your business. You can also reach a local audience by targeting ads specifically for your geographical area. Yahoo also offers certain upgrades like the Search Optimizer, which can automatically manage your keyword bids, and the Marketing Console, which tracks how effective your online campaigns are. Each of these are available for a monthly fee. Free tools include: the Keyword Selector Tool and the View Bids Tool, as well as a PPC ROI calculator and CPM ROI Calculator.
Microsoft adCenter (Bing) is relatively new in the big names of search engine PPC. Yet, it is very popular since it offers a large range of features: costs only $5 to sign up,targeted towards a buying market where the competition is not as high as Google and Yahoo, and so the amount you pay per click is lower. You can take advantage of the keyword research tool, which gives you the past month?s searches for your keyword, other relevant keywords, and the present month?s traffic for those keywords. The tool also shows trends for each keyword.
It is generally recommended that, if you are new to PPC, you start with just one search engine (preferably Google Adwords), learn how that works, and then move on to others if you feel that it might be worth a try. In recent studies done by payperclickuniverse, there are over 500 PPC search engines operating at this time, (Google Adwords, Microsoft Adcenter, and Yahoo) are the most popular that produce over 85% of all the Pay Per Click searches.
Search Engine Optimization Services
Source: http://www.onlinemediamagic.com/blog/1976/top-search-engine-ppc-platforms/
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Key Benefits Of PHP Web Development - Work On the Internet
PHP is one of the most popular scripting languages used today. It is used for creating dynamic WebPages that interact with the user offering customized information. There is more than million of websites are running in PHP around the web and so many new websites are being created from all over the world in PHP.
Many professional and experienced companies in the market are offering PHP website development services with offshore /outsource facility as well. PHP offers many advantages; it is fast, stable, secure, easy to use and open source (free).
PHP website development is a very common term in web designing and developing field.?The basic benefit of PHP web development is that, this technology makes the web pages dynamically which is the basic requirement of website owner.PHP development has lots of benefits Here are some of the basic benefits of PHP.
??It?s a simple and easy scripting language. It is easy to understand and implement, especially for those have basic knowledge of Programming such as C, javascript and HTML. Programmer will feel comfortable using and understanding PHP. This feature will make PHP a very accessible program for people from all backgrounds.
?PHP application gives quick response by using database in PHP, MySql,Informix, Oracle?etc.
?PHP is an open source techniques so any one can download it and make website in it, so that is the biggest reason of its popularity. PHP is a technique that is being allowing the php developers to get cutting edge solution in website development.
?PHP is rich in its feature one of them is its CMS system. It provides?freedom to manipulate the design according to specific needs of the websites. That?s why it is used in many Content Management Systems like WordPress, Drupal and Joomla.
?One of the basic reasons of using PHP that it is budget friendly. It is easily affordable by everyone. It is very popular among those who want to start new online business with limited budget and looking to achieve a good quality website. There is no licenses require to make website in PHP, and you can use it without any cost.
?PHP also provides a user friendly environment for developer as well as to the user. It supports different techniques and different language just like Ajax C, C++, Java?and apache, mysql, linux etc
?PHP is very flexible language. It provides wide selection of libraries, the ones used for graphics and other important features like Extensible Markup Language (XML).
?PHP services provide automated security measures against various kinds of threats or attacks. Attacks like SQL injection, XSS attacks from user inputs or cookies with malware can be mechanically destroyed by their latest infrastructural supports.
PHP have endless benefits I am able to define just some of them. Develop your PHP website and see the benefits of it.
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Article Tags : PHP Web Development, web development, php development
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